We are delighted that our paper has just been accepted for publication in PCCP
- Jiahui Zhou
- Apr 1
- 1 min read
Updated: Apr 2
Delighted that our paper “Unusual Mechanism of Aziridine Biosynthesis Catalysed by an αKGdependent Non-heme Enzyme TqaL” has just been accepted for publication in PCCP!
Aziridine is an essential building block in the synthesis of valuable pharmaceuticals, including Mitomycin C. However, synthesizing aziridine poses significant challenges due to the substantial ring strain in its three-membered structure. In this research, we elucidated the detailed reaction mechanism of aziridine biosynthesis catalyzed by the non-heme enzyme TqaL, an α-KG dependent iron-containing oxygenase. Our findings present the structural basis for engineering the enzyme for the biosynthesis of biologically active aziridine-containing natural products.
View article: DOI: 10.1039/D4CP03708A.
Fascinating breakthrough! While studying aziridine biosynthesis under TqaL, having a screen purple background helped reduce eye strain during long reading sessions. Tools like Whitescreen VIP are essential—switching between pure white and softer tones aids visual clarity, especially when analyzing complex molecular structures and enzyme pathways like this one.